Thermo Fisher Scientific TLR7 Recombinant Rabbit Monoclonal Antibody (ARC0401)
TLR7 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot과 ELISA에 적합합니다. 인간 시료에 반응하며, HEK293 세포에서 발현되었습니다. 고순도의 Affinity Chromatography 정제 제품으로, PBS 버퍼에 보관됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:500 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0401 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 950–1049 of human TLR7 (Q9NYK1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.85 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849177 |
Product Specific Information
Immunogen sequence:
SKKTVFVMTD KYAKTENFKI AFYLSHQRLM DEKVDVIILI FLEKPFQKSK FLQLRKRLCG SSVLEWPTNP QAHPYFWQCL KNALATDNHV AYSQVFKETV
Target Information
TLR7 is a highly conserved membrane protein belonging to the Toll-like receptor (TLR) family, containing 27 leucine-rich repeats (LRRs) and a TIR domain. It plays a critical role in pathogen recognition and activation of innate immunity.
TLR7 is activated by single-stranded RNA viruses such as influenza and vesicular stomatitis virus (VSV). It is predominantly expressed in the lung, placenta, and spleen, and is located near TLR8.
Through MyD88 and TRAF6 signaling, TLR7 activation leads to NF-kappaB activation, cytokine secretion, and inflammatory responses. It recognizes pathogen-associated molecular patterns (PAMPs) on infectious agents, mediating cytokine production essential for effective immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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