Thermo Fisher Scientific TLR7 Recombinant Rabbit Monoclonal Antibody (ARC0401)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:500

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0401

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 950-1049 of human TLR7 (Q9NYK1) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TLR7,uniProtId:Q9NYK1-1,ncbiNodeId:9606,antigenRange:950-1049,antigenLength:1049,antigenImageFileName:MA5-35275_TLR7_Q9NYK1-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35275_TLR7_Q9NYK1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.85 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849177

Product Specific Information

Immunogen sequence: SKKTVFVMTD KYAKTENFKI AFYLSHQRLM DEKVDVIILI FLEKPFQKSK FLQLRKRLCG SSVLEWPTNP QAHPYFWQCL KNALATDNHV AYSQVFKETV

Target Information

TLR7 is a 10 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR7 recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.