Thermo Fisher Scientific PAX2 Monoclonal Antibody (2C1B6)
PAX2 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 Flow cytometry에 적합합니다. 정제된 재조합 인간 PAX2 단편(aa 194–304)을 면역원으로 사용하였으며, Protein G로 정제된 액상 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C1B6 |
| Immunogen | Purified recombinant fragment of human PAX2 (aa 194–304) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4 °C short term. For long-term storage, store at −20 °C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898501 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
The PAX gene family encodes transcription factors active during early embryonic development. Members possess a DNA-binding domain encoded by the paired box and regulate genetic programs essential for tissue differentiation.
Several PAX genes are linked to developmental disorders:
- PAX3: associated with Waardenburg syndrome
- PAX6: associated with Aniridia
- PAX2: associated with Wilms tumor
During embryogenesis, PAX2 is expressed in the developing kidney, particularly in condensing metanephric mesenchyme and early epithelial structures derived from mesenchyme. Expression decreases as the tubular epithelium matures. Persistent expression of PAX2 in Wilms tumors correlates with poorly differentiated epithelial cell proliferation. WT1, the Wilms tumor suppressor protein, is thought to repress PAX2 transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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