Thermo Fisher Scientific MST1 (STK4) Monoclonal Antibody (1G5H4)

Applications

• ELISA (ELISA): 1:1,000–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human STK4/MST1.

Target Information

STK4 (MST1) is a serine/threonine kinase potentially involved in apoptosis. It may induce chromatin condensation during this process. STK4 is a stress-activated, pro-apoptotic kinase that, upon caspase cleavage, enters the nucleus to trigger chromatin condensation and DNA fragmentation.
It is a key component of the Hippo signaling pathway, crucial for organ size control and tumor suppression by limiting proliferation and promoting apoptosis. The pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, with SAV1, activate LATS1/2 (with MOB1), which then phosphorylates and inactivates YAP1 and WWTR1/TAZ.
Phosphorylation of YAP1 by LATS2 prevents its nuclear translocation, regulating genes involved in cell proliferation, death, and migration. STK3/MST2 and STK4/MST1 are essential for repressing hepatocyte proliferation, preventing activation of oval cells, and inhibiting tumor formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.