Thermo Fisher Scientific CLCNKA Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 470-644 of human CLCNKA (NP_0012440681) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CLCNKA,uniProtId:P51800-1,ncbiNodeId:9606,antigenRange:470-644,antigenLength:687,antigenImageFileName:PA5-92064_CLCNKA_P51800-1_Rabbit.svg,antigenImageFileNamePDP:PA5-92064_CLCNKA_P51800-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806370

Product Specific Information

Immunogen sequence: QSCQPSFYDG TIIVKKLPYL PRILGRNIGS HHVRVEHFMN HSITTLAKDT PLEEVVKVVT STDVTEYPLV ESTESQILVG IVQRAQLVQA LQAEPPSRAP GHQQCLQDIL ARGCPTEPVT LTLFSETTLH QAQNLFKLLN LQSLFVTSRG RAVGCVSWVE MKKAISNLTN PPAPK; Positive Samples: LO2, HT-29, A-549; Cellular Location: Membrane, Multi-pass membrane protein

Target Information

CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter`s syndrome which is characterized by renal salt-wasting and low blood pressure.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.