Thermo Fisher Scientific CLCNKA Polyclonal Antibody
Rabbit polyclonal antibody against human and mouse CLCNKA. Validated for WB and ELISA. Recognizes membrane multi-pass protein involved in renal chloride transport. Supplied as liquid, affinity purified, 0.18 mg/mL in PBS with 50% glycerol. For research...
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 470–644 of human CLCNKA (NP_001244068.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.18 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806370 |
Product Specific Information
Immunogen sequence:
QSCQPSFYDG TIIVKKLPYL PRILGRNIGS HHVRVEHFMN HSITTLAKDT PLEEVVKVVT STDVTEYPLV ESTESQILVG IVQRAQLVQA LQAEPPSRAP GHQQCLQDIL ARGCPTEPVT LTLFSETTLH QAQNLFKLLN LQSLFVTSRG RAVGCVSWVE MKKAISNLTN PPAPK
Positive Samples: LO2, HT-29, A-549
Cellular Location: Membrane, Multi-pass membrane protein
Target Information
CLC-KA is a kidney-specific chloride channel mediating transepithelial chloride transport in the thin ascending limb of the Henle loop within the inner medulla. It plays a crucial role in urine concentration.
The human CLC-KA gene maps to chromosome 1p36. Mutations may be associated with nephrogenic diabetes insipidus when vasopressin V2 receptor and AQP2 mutations are absent.
CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and distal nephron segments. Mutations in CLC-KB cause type III Bartter’s syndrome, characterized by renal salt wasting and low blood pressure.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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