Thermo Fisher Scientific Biliverdin Reductase Polyclonal Antibody
Thermo Fisher Scientific의 Biliverdin Reductase Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 토끼 IgG 항체입니다. Western blot 및 IHC(P) 분석에 적합하며, BLVRA 단백질(aa 1-296)을 면역원으로 사용했습니다. 고순도 친화 크로마토그래피 정제, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:200
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–296 of human BLVRA (NP_001240752.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.37 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806368 |
Product Specific Information
Immunogen sequence:
MNAEPERKFG VVVVGVGRAG SVRMRDLRNP HPSSAFLNLI GFVSRRELGS IDGVQQISLE DALSSQEVEV AYICSESSSH EDYIRQFLNA GKHVLVEYPM TLSLAAAQEL WELAEQKGKV LHEEHVELLM EEFAFLKKEV VGKDLLKGSL LFTAGPLEEE RFGFPAFSGI SRLTWLVSLF GELSLVSATL EERKEDQYMK MTVCLETEKK SPLSWIEEKG PGLKRNRYLS FHFKSGSLEN VPNVGVNKNI FLKDQNIFVQ KLLGQFSEKE LAAEKKRILH CLGLAEEIQK YCCSRK
Positive Samples: Mouse kidney
Cellular Location: Cytoplasm
Target Information
Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, converting heme to iron, carbon monoxide, and biliverdin.
BLVR is unique in being dual pH/dual cofactor-dependent, requiring NADH (pH 6.7) or NADPH (pH 8.7) as an electron donor.
There are two isoforms:
- BLVRA (biliverdin-IX alpha-reductase): Major component of human adult liver
- BLVRB (biliverdin-IX beta-reductase): Found predominantly in fetal liver
The product of BLVR, bilirubin, is an important biological antioxidant but also a neurotoxin causing kernicterus. In addition to antioxidant activity, it inhibits kinase activity and enzymes such as protein kinase C and NADPH oxidase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-92059_Biliverdin_Reductase_P53004-1_Rabbit.svg, PA5-92059_Biliverdin_Reductase_P53004-1_Rabbit_PDP.jpeg)
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