Thermo Fisher Scientific Thymidylate Synthase Recombinant Rabbit Monoclonal Antibody (JM33-20)
Thymidylate Synthase 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, Flow Cytometry에 적합합니다. 높은 특이성과 재현성을 제공하며, 단백질 A 정제 및 동물 유래 성분이 없는 포뮬레이션으로 제조되었습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM33-20 |
| Immunogen | Synthetic peptide within Human Thymidylate Synthase aa 264–313 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810010 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening of individual clones to select optimal candidates.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
Thymidylate Synthase (TS) catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), a critical step in DNA biosynthesis.
TS is a key target of fluoropyrimidine-based anticancer drugs such as 5-fluorouracil (5-FU) and fluorodeoxyuridine. These compounds are converted in tumor cells to FdUMP, which inactivates TS by forming a ternary covalent complex with the folate cofactor 5,10-methylenetetrahydrofolate.
Expression of TS correlates with response to 5-FU in human colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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