Thermo Fisher Scientific STAT4 Monoclonal Antibody (OTI4H6), TrueMAB
STAT4 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Human 시료에 반응합니다. Western blot, IHC, Flow cytometry 등 다양한 응용에 사용 가능하며, IL-12 매개 Th1 반응 연구에 적합합니다. Lyophilized 형태로 -20°C 보관, 재구성 및 conjugation 실험에 활용 가능합니다.
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Thermo Fisher Scientific STAT4 Monoclonal Antibody (OTI4H6), TrueMAB
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4H6 |
| Immunogen | Full length human recombinant protein of human STAT4 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended desalting method: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
STAT4 was identified using degenerate primers targeting conserved STAT protein regions. It shares similarity with STAT1 (52%) and STAT3 (47%). STAT4 can be phosphorylated by Jak1 or Jak2, forming homo- and heterodimers with other STATs. Tyrosine-phosphorylated STAT4 binds IFN-gamma activated sites (GAS), and serine phosphorylation enhances transcriptional activity.
STAT4 expression is mainly in thymus, spleen, and testis. It is activated by interleukin 12 (IL-12), which induces IFN-gamma production and Th1 response development essential for defense against intracellular pathogens. STAT4-deficient mice show impaired Th1 and enhanced Th2 development. STAT4 activation by IFN-a/b is also required for IFN-g production during viral infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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