Thermo Fisher Scientific TIMD4 Recombinant Rat Monoclonal Antibody (3A1)
마우스 TIM-4 단백질을 특이적으로 인식하는 레트 모노클로날 항체입니다. ICC, Flow, ELISA 등 다양한 면역 분석에 사용 가능하며, HEK293 세포에서 발현된 재조합 항체입니다. 단기 4°C, 장기 -20°C 보관을 권장합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
ELISA
- Tested Dilution: Assay-dependent
Functional Assay
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3A1 |
| Immunogen | Female Lewis rats immunized with Tim-4:Ig fusion protein in complete Freund’s adjuvant |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_3074603 |
Product Specific Information
This antibody is specific for murine TIM-4, which unlike other TIM family members, is not expressed on T lymphocytes but rather found on antigen-presenting cells such as lymphoid and myeloid dendritic cells and macrophages.
Target Information
The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors involved in the regulation of Th1 and Th2 cell-mediated immunity.
TIM-4 is preferentially expressed on macrophages and dendritic cells and acts as the natural ligand of TIM-1, promoting T-cell expansion and cytokine production.
Unlike other TIM family members, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain.
The TIM-4 gene maps to a locus associated with asthma predisposition in both mice and humans and may be considered a candidate gene for asthma susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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