Thermo Fisher Scientific PERK Recombinant Rabbit Monoclonal Antibody (PSH0-81)
Recombinant rabbit monoclonal antibody targeting human PERK (EIF2AK3). Validated for Western blot at 1:1,000 dilution. High specificity and purity via Protein A purification. Suitable for detecting ER stress-related signaling proteins. For research use...
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PSH0-81 |
| Immunogen | Recombinant protein within human PERK aa 51–450/1,116 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3093066 |
Product Specific Information
- Sequence Similarities: 87% Mouse / 98% Rat
- Tissue Specificity: Ubiquitous; high expression in secretory tissues
- Positive Control Samples: MCF7, HepG2, HEK-293, HeLa, A549, U-87 MG, K-562 cell lysates
- Subcellular Location: Endoplasmic reticulum membrane
- Predicted Band Size: 125 kDa
Target Information
EIF2AK3 (PERK) is one of four kinases that phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to environmental stress, leading to reduced protein synthesis. PERK signaling is triggered by misfolded proteins in the endoplasmic reticulum.
Defects in EIF2AK3 cause Wolcott-Rallison syndrome (WRS), a rare autosomal recessive disorder characterized by neonatal or early-onset insulin-dependent diabetes, epiphyseal dysplasia, osteoporosis, growth retardation, and multisystem abnormalities including hepatic, renal, mental, and cardiovascular dysfunctions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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