Thermo Fisher Scientific SIAH1 Recombinant Rabbit Monoclonal Antibody (PSH01-80)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Immunocytochemistry (ICC/IF)

1:100

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

PSH01-80

Immunogen

Synthetic peptide within human siah1 aa 1-50/282. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SIAH1,uniProtId:Q8IUQ4-1,ncbiNodeId:9606,antigenRange:1-50,antigenLength:282,antigenImageFileName:MA5-51926_SIAH1_Q8IUQ4-1_Rabbit.svg,antigenImageFileNamePDP:MA5-51926_SIAH1_Q8IUQ4-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3094388

Product Specific Information

Sequence Similarities: 100% Mouse/Rat.

Tissue Specificity: Widely expressed at a low level. Down-regulated in advanced hepatocellular carcinomas.

Positive Control: HCT 116 cell lysate, RAW264.7 cell lysate, mouse liver tissue lysate, mouse brain tissue lysate, rat liver tissue lysate, rat brain tissue lysate, Rat testis testis lysate, A549.

Subcellular Location: Cytoplasm, Nucleus.

Predicted band size: 31 kDa.

Target Information

This gene encodes a protein that is a member of the seven in absentia homolog family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson`s disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.