Thermo Fisher Scientific Pericentrin Recombinant Rabbit Monoclonal Antibody (PSH0-66)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:500

-

Immunocytochemistry (ICC/IF)

1:300

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

PSH0-66

Immunogen

Recombinant protein within human aa 201-600/3,336. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Pericentrin,uniProtId:O95613-1,ncbiNodeId:9606,antigenRange:201-600,antigenLength:3336,antigenImageFileName:MA5-51929_Pericentrin_O95613-1_Rabbit.svg,antigenImageFileNamePDP:MA5-51929_Pericentrin_O95613-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3093065

Product Specific Information

Sequence Similarities: 63% Mouse/No Cross with Rat.

Tissue Specificity: Expressed in all tissues tested, including placenta, liver, kidney and thymus.

Positive Control: HeLa cell lysate, HepG2 cell lysate, MCF7 cell lysate, K-562 cell lysate.

Subcellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Predicted band size: 378 kDa.

Target Information

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.