Thermo Fisher Scientific CD4 Monoclonal Antibody (SK3 (SK-3)), FITC, eBioscience
인간 CD4 항원을 인식하는 SK3 클론 단일클론 항체로, FITC 형광 표지되어 있습니다. Flow Cytometry용으로 최적화되어 있으며 HIV 수용체 연구 및 T 세포 분석에 적합합니다. 액상 형태로 제공되며 4°C 암소 보관합니다.
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Thermo Fisher Scientific CD4 Monoclonal Antibody (SK3 (SK-3)), FITC, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.06 µg)/test
Publications: View 14 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SK3 (SK-3) |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1272143 |
Additional Formats Available
- Alexa Fluor 532
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV 395 / 496 / 563 / 737 / 805
- Brilliant Violet 421 / 605
- eFluor 450
- NovaFluor Blue, Red, Violet, Yellow series (multiple wavelengths)
- PE / PE-Cyanine5.5 / PE-Cyanine7 / PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436 / 600 / 645 / 702 / 780
- Request custom conjugation
Product Specific Information
The SK3 monoclonal antibody reacts with human CD4, a 59-kDa cell surface receptor expressed by most thymocytes, a subset of mature T helper cells, and at low levels by monocytes. CD4 serves as a receptor for HIV. SK3 blocks HIV binding and mixed lymphocyte reactions. The SK3 and RPA-T4 monoclonal antibodies recognize distinct epitopes.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested on normal human peripheral blood cells at 5 µL (0.06 µg) per test (100 µL final volume).
Cell number range: 10⁵–10⁸ cells/test
Excitation: 488 nm
Emission: 520 nm
Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD4 antigen is involved in MHC class II recognition and acts as a co-receptor for HIV. It is primarily expressed in T helper cells but also found in monocytes, macrophages, and dendritic cells. CD4 expression is detectable in thymus, lymph nodes, tonsils, spleen, and certain non-lymphoid tissues. It contributes to T-cell activation via interaction with the T-cell receptor complex and Lck kinase. CD4 may also mediate neuronal damage in infectious and immune-related CNS diseases.
Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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