Thermo Fisher Scientific TTC21B Polyclonal Antibody
TTC21B 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. IHC(P) 및 ICC/IF 실험에 적합하며, 항원 친화 크로마토그래피로 정제됨. Human 반응성, 비결합형 액상 형태로 제공되며 4°C 또는 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TTC21B. Recombinant protein control fragment (Product # RP-96060) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649046 |
Product Specific Information
Immunogen sequence:
ALAHEPVNEL SALMEDGRCQ VLLAKVYSKM EKLGDAITAL QQARELQARV LKRVQMEQPD AVPAQKHLAA EICAEIAKHS VAQRDYE
Highest antigen sequence identity to the following orthologs:
- Mouse: 86%
- Rat: 86%
Target Information
The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity.
TTC21B (tetratricopeptide repeat domain 21B), also known as THM1, is a 1,316 amino acid protein that contains 19 TPR repeats and belongs to the TTC21 family. Localizing to cytoplasm and cytoskeleton, TTC21B exists as two alternatively spliced isoforms and is thought to negatively regulate Shh signal transduction. TTC21B may also be involved in retrograde intraflagellar transport in cilia, and is encoded by a gene that maps to human chromosome 2q24.3.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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