Thermo Fisher Scientific HNMT Polyclonal Antibody
Thermo Fisher Scientific의 HNMT Polyclonal Antibody는 인간 HNMT 단백질에 특이적인 토끼 IgG 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HNMT. Recombinant protein control fragment (Product #RP-96136). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642492 |
Product Specific Information
Immunogen sequence:
SMRSLFSDHG KYVESFRRFL NHSTEHQCMQ EFMDKKLPGI IGRIGDTKSE IKILSIGGGA GEIDLQILSK VQAQYPGVCI NNEVVEPSAE QIAKYK
Highest antigen sequence identity to the following orthologs:
- Mouse: 88%
- Rat: 90%
Target Information
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase (HNMT) and oxidative deamination via diamine oxidase.
HNMT is a cytosolic enzyme that uses S-adenosyl-L-methionine as the methyl donor.
In the mammalian brain, histamine neurotransmitter activity is regulated by N(tau)-methylation since diamine oxidase is absent in the central nervous system.
A common genetic polymorphism affects HNMT activity levels in red blood cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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