Thermo Fisher Scientific Phospho-ANKRD28 (Ser1007) Polyclonal Antibody
ANKRD28 단백질의 Ser1007 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P)에서 사용 가능. 인간 및 마우스 시료에 반응. PBS/glycerol buffer에 보관되며, -20°C에서 안정적 저장 가능.
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- PA5105964
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ANKRD28 (Accession O15084), corresponding to amino acid residues around phosphorylated Ser1007. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817363 |
Product Specific Information
Antibody detects endogenous levels of ANKRD28 only when phosphorylated at Ser1007.
Target Information
ANKRD28 is a putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. It participates in PP6-mediated dephosphorylation of NFKBIE, opposing its degradation in response to TNF-alpha. ANKRD28 selectively inhibits the phosphatase activity of PPP1C and modulates HNRPK phosphorylation. It regulates phosphorylation of hnRNP-K at Ser284, suggesting a role in targeted dephosphorylation through PP1 interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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