Thermo Fisher Scientific Phospho-BAG3 (Tyr457) Polyclonal Antibody
Phospho-BAG3 (Tyr457) 폴리클로날 항체로 인산화된 BAG3 단백질을 특이적으로 검출. Western blot 및 IHC(P) 분석에 적합. 인간, 생쥐, 랫트 반응성. 고순도 액상 형태로 -20°C 보관.
- 카탈로그번호
- PA5105968
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BAG3 (Accession O95817), corresponding to amino acid residues around phosphorylated Tyr457 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817367 |
Product Specific Information
Antibody detects endogenous levels of BAG3 only when phosphorylated at Tyr457.
Target Information
BAG3 belongs to the BAG protein family that competes with Hip for binding to the Hsc70/Hsp70 ATPase domain and promotes substrate release. All BAG proteins possess a BAG domain near the C terminus but differ in their N-terminal regions. BAG3 contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain and inhibit its chaperone activity in a Hip-repressible manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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