Thermo Fisher Scientific p53R2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered.
p53R2 is a p53-inducible gene containing a p53 binding sequence and encodes a subunit of ribonucleotide reductase. It is induced by ultraviolet and gamma irradiation that cause DNA damage. The p53R2 gene product is directly involved in the p53 checkpoint for DNA repair. The isoform of the p53 family member p73 also induces p53R2 expression, making p53R2 an important target of p53 for tumor suppression.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.