Thermo Fisher Scientific CTLA-4 Recombinant Armenian Hamster Monoclonal Antibody (9H10)
마우스 CTLA-4에 특이적인 아르메니아 햄스터 유래 재조합 단클론 항체. WB, Flow, ELISA, Neutralization 등 다양한 어세이에 사용 가능. HEK293 세포에서 발현, Protein A로 정제된 액상 형태. 면역억제 수용체 연구 및 T세포 반응 조절 분석에 적합.
- 카탈로그번호
- MA551808
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Thermo Fisher Scientific CTLA-4 Recombinant Armenian Hamster Monoclonal Antibody (9H10)
Applications and Tested Dilution
- Western Blot (WB): Assay-dependent
- Flow Cytometry (Flow): Assay-dependent
- ELISA (ELISA): Assay-dependent
- Neutralization (Neu): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Armenian hamster / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9H10 |
| Immunogen | Syrian hamsters immunized with Staphylococcus A bacteria coated in CTLA-4; B cells fused with P3X3.Ag8.653 myeloma line to produce stable hybridomas |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody is specific for murine CTLA-4, an inhibitory receptor that acts as the primary negative regulator of T-cell responses. CTLA-4 is expressed predominantly by activated T cells, with significantly higher levels of expression on CD8+ T cells than CD4+ T cells.
Target Information
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed mainly on CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells) but with higher affinity. Unlike CD28, which enhances T-cell activation, CTLA4 inhibits T-cell function. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their suppressive function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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