Thermo Fisher Scientific CCNG1 Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Protein Sequence:
MIEVLTTTDS QKLLHQLNAL LEQESRCQPK VCGLRLIESA HDNGLRMTAR LRDFEVKDLL SLTQFFGFDT ETFSLAVNLL DRFLSKMKVQ PKHLGCVGLS CFYLAVKSIE EERNVPLATD LIRISQYRFT VSDLMRMEKI VLEKVCWKVK ATTAFQFLQL YYSLLQENLP LERRNSINFE RLEAQLKACH CRIIFSKAKP SVLALSIIAL EIQAQKCVEL TEGIECLQKH SKINGRDLTF WQELVSKCLT EYSSNKCSKP NVQKLKWIVS GRTARQLKHS YYRITHLPTI PEMVP

Target Information

Cyclins are regulatory subunits of Cdc2 p34 and related cyclin-dependent kinases (Cdks) that play critical roles in cell cycle progression.

• Cyclin A and B form complexes with Cdc2 p34 kinase to control G2 to M transition and S phase progression.
• G1 cyclins regulate the G1 to S transition, with Cyclin D1 interacting with Cdk2, Cdk4, and Cdk5.
• Cyclin E and Cdk2 interact during the G1 to S transition.
• Cyclin G contains an N-terminal cyclin box and a C-terminal domain homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor.
• Cyclin G expression is induced within 3 hours after growth stimulation and remains elevated without cell cycle dependency.
• Cyclin G2 shares 53% sequence identity with Cyclin G1, with peak expression in late S phase, whereas Cyclin G1 expression is constitutive.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.