Thermo Fisher Scientific Cytokeratin 18 Polyclonal Antibody

Thermo Fisher Scientific Cytokeratin 18 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Positive test controls include: HeLa, HT-29, HepG2, K-562, Mouse liver, Mouse kidney.
The target is usually found in the following locations: Cytoplasm, Nucleus, nucleolus, perinuclear region.

Immunogen sequence:
SHYFKIIEDL RAQIFANTVD NARIVLQIDN ARLAADDFRV KYETELAMRQ SVENDIHGLR KVIDDTNITR LQLETEIEAL KEELLFMKKN HEEEVKGLQA QIASSGLTVE VDAPKSQDLA KIMADIRAQY DELARKNREE LDKYWSQQIE ESTTVVTTQS AEVGAAETTL TELRRTVQSL EIDLDSMRNL KASLENSLRE VEARYALQME QLNGILLHLE SELAQTRAEG QRQAQEYEAL LNIKVKLEAE IATYRRLLED GEDFNLGDAL DSSNSMQTIQ KTTTRRIVDG KVVSETNDTK VLRH

Target Information

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin 8.
It is expressed in tissues from the gastrointestinal, respiratory, and urogenital tracts, as well as endocrine, exocrine, and mesothelial cells.
Cytokeratin 18 is found primarily in non-squamous epithelia and is present in most adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas.
Hepatocellular carcinomas express only cytokeratins 8 and 18.
Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis.
Two transcript variants encoding the same protein have been found for the cytokeratin 18 gene.
Cytokeratin subtype expression patterns are used increasingly for distinguishing epithelial malignancies.
Cytokeratin antibodies assist in tumor differential diagnosis using immunohistochemistry and are useful in cytopathology and flow cytometric assays.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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