Thermo Fisher Scientific HINT1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive test controls: 22Rv1, HeLa, H460, K-562, Mouse kidney, Mouse liver, Rat kidney, Rat liver
• Target localization: Cytoplasm, Nucleus

Immunogen sequence:
MADEIAKAQV ARPGGDTIFG KIIRKEIPAK IIFEDDRCLA FHDISPQAPT HFLVIPKKHI SQISVAEDDD ESLLGHLMIV GKKCAADLGL NKGYRMVVNE GSDGGQSVYH VHLHVLGGRQ MHWPPG

Target Information

Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities.
HINT1 catalyzes the hydrolysis of adenosine 5'-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression.
Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, which could contribute to its tumor suppressor activity. Other studies suggest HINT1 as a candidate gene for schizophrenia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.