Thermo Fisher Scientific alpha-1a Adrenergic Receptor Recombinant Rabbit Monoclonal Antibody (4G10W8)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen Sequence:
VWALSLVISI GPLFGWRQPA PEDETICQIN EEPGYVLFSA LGSFYLPLAI ILVMYCRVYV VAKRESRGLK SGLKTDKSDS EQVTLRIHRK NAPAGGSGMA S

Target Information

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family.

Nine receptor subtypes have been identified thus far, including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.

Alpha-1A adrenergic receptor (A1AR) subtypes are found in numerous tissues and are involved in blood pressure regulation through vascular tone and cardiac output modulation. A1AR activation has also been linked to uterine contraction, hepatic glucose metabolism, heat shock protein 70 (HSP70) expression, proto-oncogene expression, and mitogenesis. Norepinephrine can increase nitric oxide synthase (NOS) levels in the hypothalamus by activating alpha-1 AR, which may indirectly suppress the release of luteinizing hormone (LH), androgens, estrogen, and progesterone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.