Thermo Fisher Scientific TMEM16B (ANO2) (extracellular) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitution:
  Reconstitute with 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
  The antibody is shipped as a lyophilized powder at room temperature and should be stored at -20°C upon arrival.
  The reconstituted solution can be stored at 4°C for up to 1 week. For long-term storage, aliquot and store at -20°C.
  Avoid multiple freeze/thaw cycles.
  Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Calcium-activated chloride channels (CaCCs) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction.
Subunits of these CaCCs include the transmembrane proteins TMEM16A and TMEM16B.
TMEM16B is predicted to have eight transmembrane domains with both the amino and carboxy termini in the cytoplasm and is expressed in several tissues, including olfactory sensory neurons and photoreceptors in the mammalian retina.
Like TMEM16A, TMEM16B is thought to form at least part of CaCCs but has different biophysical characteristics such as voltage dependence and unitary conductance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.