Thermo Fisher Scientific MDMX Polyclonal Antibody
Human MDMX 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot 및 Immunocytochemistry에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MDM4 (MDMX). Recombinant protein control fragment (Product #RP-104863). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791082 |
Product Specific Information
Immunogen sequence:
LSDDTDVEVT SEDEWQCTEC KKFNSPSKRY CFRCWALRKD WYSDCSKLTH SLSTSDITAI PEKENEGNDV PDCRRTISAP VVRPKDAYIK KENS
Target Information
The MDM2 protein is the primary regulator of p53 protein stability. MDMX (also designated MDM4) is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene encoding MDMX is a target for amplification in malignant gliomas. ARF interacts with MDMX to sequester it within the nucleolus, leading to increased p53 transactivation. Expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. Like MDM2, MDMX also binds and stabilizes p73, increasing its half-life.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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