Thermo Fisher Scientific Human DRAM Synthetic Peptide
휴먼 DRAM 단백질의 카복시 말단 근처 16 아미노산 서열로 구성된 합성 펩타이드. DRAM 항체(PA5-20335)의 블로킹 펩타이드로 사용 가능. 자가포식 연구 및 p53 관련 세포사멸 경로 연구에 적합. 연구용으로만 사용.
- 카탈로그번호
- PEP0455
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to a 16 amino acid sequence from near the carboxy terminus of human DRAM.
PEP-0455 can be used as a blocking peptide with polyclonal antibody PA5-20335.
Target Information
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs simultaneously with activation of proapoptotic genes such as PUMA and Bax, promoting a full cell death response. DRAM alone cannot induce apoptosis, but its inactivation in certain cancers indicates its importance and suggests that autophagy may play a more significant role in cancer than initially thought. At least two isoforms of DRAM are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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