Thermo Fisher Scientific Human DRAM Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to a 16 amino acid sequence from near the carboxy terminus of human DRAM.
PEP-0455 can be used as a blocking peptide with polyclonal antibody PA5-20335.

Target Information

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs simultaneously with activation of proapoptotic genes such as PUMA and Bax, promoting a full cell death response. DRAM alone cannot induce apoptosis, but its inactivation in certain cancers indicates its importance and suggests that autophagy may play a more significant role in cancer than initially thought. At least two isoforms of DRAM are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.