Thermo Fisher Scientific Human DRAM Synthetic Peptide
인간 DRAM 단백질의 N-말단 부근 16개 아미노산 서열에 해당하는 합성 펩타이드입니다. DRAM 항체(PA5-20336)와 함께 블로킹 펩타이드로 사용 가능합니다. 순도 높은 액상 형태로 제공되며, PBS 버퍼(pH 7.2, 0.1% BSA)와 sodium azide를 포함합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PEP0456
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human DRAM Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to a 16 amino acid sequence from near the amino terminus of human DRAM.
PEP-0456 can be used as a blocking peptide with polyclonal antibody PA5-20336.
Target Information
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs alongside activation of proapoptotic genes such as PUMA and Bax, together promoting a full cell death response.
DRAM alone cannot induce apoptosis, but its inactivation in certain cancers underscores its importance and suggests that autophagy may play a significant role in cancer biology.
At least two different isoforms of DRAM are known to exist.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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