Thermo Fisher Scientific Human DRAM Synthetic Peptide

Thermo Fisher Scientific Human DRAM Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to a 16 amino acid sequence from near the amino terminus of human DRAM.
PEP-0456 can be used as a blocking peptide with polyclonal antibody PA5-20336.

Target Information

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs alongside activation of proapoptotic genes such as PUMA and Bax, together promoting a full cell death response.
DRAM alone cannot induce apoptosis, but its inactivation in certain cancers underscores its importance and suggests that autophagy may play a significant role in cancer biology.
At least two different isoforms of DRAM are known to exist.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.