Thermo Fisher Scientific Human CRTH2 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to a 15 amino acid sequence from near the center of human CRTH2.
PEP-0453 can be used as a blocking peptide with polyclonal antibody PA5-20333.

Target Information

CRTH2 (GPR44) is a chemoattractant receptor-homologous molecule expressed on Th2 cells and serves as a receptor for prostaglandin D2 (PGD2). It mediates chemotaxis of Th2 cells and eosinophils to PGD2, playing a key role in allergic responses.
CRTH2-deficient mice exhibit enhanced eosinophil recruitment and elevated IL-5 and IL-3 levels, suggesting a regulatory role in allergic inflammation.
This receptor is a member of the G protein-coupled leukocyte chemoattractant receptor family, selectively expressed in Th2 cells.
CRTH2 expression has been reported in the central nervous system, peripheral tissues, and blood cells, particularly in activated Th2 cells. Two transcripts (3.5 kb and 3.4 kb) have been identified, showing tissue-specific expression patterns.
CRTH2 is implicated in Th2-type immune reactions and allergic responses, with known isoforms and SNPs in its 3′ UTR associated with asthma susceptibility.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.