Thermo Fisher Scientific CD59 Monoclonal Antibody (MEM-129)
인간 및 돼지 CD59 단백질을 인식하는 마우스 IgM 단클론 항체입니다. Flow cytometry와 기능적 분석에 적합하며, 액상 형태로 1 mg/mL 농도로 제공됩니다. 보존제 없이 TBS(pH 8.0)에 저장되며 4°C에서 보관합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1–4 µg/mL
Functional Assay (Functional)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Pig |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-129 |
| Immunogen | Human peripheral blood lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | TBS, pH 8.0 |
| Contains | No preservative |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073181 |
Product Specific Information
This antibody reacts with CD59 (Protectin), an 18–20 kDa GPI-anchored extracellular glycoprotein expressed on all hematopoietic cells and widely present on cells in all tissues.
Functional Application: Activation
Target Information
CD59 (Protectin) is a small (18–20 kDa) GPI-anchored, ubiquitously expressed inhibitor of the membrane attack complex (MAC).
It regulates complement activity by binding C8 and/or C9 during MAC assembly, preventing excessive pore formation in cell membranes.
CD59 also interacts with the C5b-8 complex and serves as a low-affinity ligand for human CD2, contributing to T-cell costimulation and lymphocyte signal transduction.
Mutations in CD59 can lead to CD59 deficiency, associated with hemolytic anemia, thrombosis, and cerebral infarction.
Multiple alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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