Thermo Fisher Scientific Phospho-Chemokine Receptor 5 (Thr340) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Product Specifications

Target Information

Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, and CCR8 in the chemokine receptor family, and four new human molecules (GPR15, STRL33, GPR1, and V28) were recently identified as HIV coreceptors.
Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, mediating fusion and entry of human white blood cells. CCR5 is required for infection by HIV-1, HIV-2, and SIV.
The beta-chemokines RANTES, MIP-α, and MIP-β are ligands for CCR5 and prevent infection by M-tropic HIV-1. CCR5 associates with the surface CD4-gp120 of the HIV complex, leading to membrane fusion and viral entry into target cells. The amino-terminal domain and extracellular loops of CCR5 serve as HIV binding sites. CCR5 mRNA is expressed in lymphoid organs and monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.