Thermo Fisher Scientific Phospho-CCR5 (Ser349) Polyclonal Antibody
Phospho-CCR5 (Ser349) 폴리클로날 항체로, 인산화된 CCR5 단백질의 Ser349 잔기를 특이적으로 인식합니다. Western blot 및 ICC/IF에 사용 가능하며, 인간 시료에 반응합니다. 순도 높은 항체로 PBS/glycerol 용액에 보관됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CCR5 (Accession P51681), corresponding to amino acid residues around phosphorylated Ser349. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815999 |
Product Specific Information
This antibody detects endogenous levels of CCR5 only when phosphorylated at serine 349.
Target Information
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Several G protein-coupled receptors, including CCR5, CXCR4, CCR3, CCR2b, and CCR8, act as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, facilitating fusion and entry into human white blood cells.
CCR5 is essential for infection by HIV-1, HIV-2, and SIV. Beta-chemokines such as RANTES, MIP-alpha, and MIP-beta are ligands for CCR5 and can prevent infection by M-tropic HIV-1. CCR5 associates with the surface CD4-gp120 complex of HIV, leading to membrane fusion and viral entry. The amino-terminal domain and extracellular loops of CCR5 serve as HIV binding sites. CCR5 mRNA is expressed in lymphoid organs and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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