Thermo Fisher Scientific Phospho-CD227 (Mucin 1) (Tyr1229) Polyclonal Antibody
Phospho-CD227 (MUC1) Tyr1229 특이적 폴리클로날 항체로, 인산화된 MUC1 단백질의 내인성 수준을 검출. Western blot, IHC, ICC/IF에 사용 가능. 사람 및 마우스 반응성, Rabbit IgG, 액상 형태로 제공. 연구용 전용 제품.
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Thermo Fisher Scientific Phospho-CD227 (Mucin 1) (Tyr1229) Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MUC1 (Accession P15941), corresponding to amino acid residues around phosphorylated Tyr1229 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816000 |
Product Specific Information
Antibody detects endogenous levels of CD227/MUC1 only when phosphorylated at Tyrosine 1229.
Target Information
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages.
It is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through proteolysis and extensive O-linked glycosylation.
MUC1 is highly polymorphic, with alleles encoding different numbers of tandem repeats (30–90), resulting in variable molecular weights.
It is abundantly expressed in >90% breast carcinomas and metastases.
Overexpression, aberrant localization, and altered glycosylation of MUC1 are associated with carcinomas.
Multiple alternatively spliced variants exist, with some full-length forms characterized.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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