Thermo Fisher Scientific M-CSF Recombinant Rabbit Monoclonal Antibody (23GB5110)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Flow Cytometry (Flow)

• Tested Dilution: 1:2,000

Product Specifications

Target Information

M-CSF (Macrophage colony-stimulating factor, CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. It also induces VEGF secretion by macrophages, mediating mobilization of endothelial progenitor cells and neovascularization.
M-CSF exists as several bioactive isoforms differing in potency and stability. The full-length protein is synthesized as a membrane-spanning form that can be cleaved and modified in secretory vesicles.
It forms a disulfide-bonded homodimer processed into glycoprotein or proteoglycan isoforms. Binding to its receptor c-Fms (CSF-1R or CD115) induces receptor dimerization, internalization, and degradation.
Functionally, M-CSF stimulates differentiation of hematopoietic stem cells into monocyte-macrophage populations. It acts through CSF receptor 1. Human M-CSF shows activity on mouse cells, but mouse CSF shows no activity on human cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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