Thermo Fisher Scientific Kaiso Polyclonal Antibody
Kaiso 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 인간 단백질에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 622 and 672 of human Transcriptional regulator Kaiso |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, binding to methylated CGCG and the non-methylated consensus KAISO-binding site TCCTGCNA.
The protein contains an N-terminal POZ/BTB domain and three C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and repressive chromatin formation in target gene promoters.
It may repress Wnt signaling pathway target genes and activate transcription of a subset of genes via catenin delta-2 (CTNND2) recruitment. Interaction with catenin delta-1 (CTNND1) inhibits DNA binding. It also interacts with Importin-alpha 2 (karyopherin alpha2), mediating nuclear import.
Alternatively spliced transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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