Thermo Fisher Scientific Furin Polyclonal Antibody
Goat에서 유래한 Furin 폴리클로날 항체로, Western blot 등 연구용에 적합합니다. Human 시료에 반응하며, 비결합(Unconjugated) 상태로 제공됩니다. 0.5 mg/mL 농도의 액상 형태로, TBS(pH 7.3) 및 0.5% BSA 함유. -20°C에서 보관 권장.
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- PA5142900
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Applications
Western Blot (WB)
- Tested Dilution: 0.01–0.03 µg/mL
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-EDEGRGERTAFIKDQ |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933543 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Furin is a membrane-associated, calcium-dependent serine protease belonging to the subtilisin-like prohormone convertase (PC) family. These enzymes cleave prohormones and neuropeptide precursors, as well as various cellular, viral, and bacterial proteins transported via the constitutive secretory pathway.
Furin and other PC family members share structural similarities, including:
- A heterogeneous ~10 kDa amino-terminal proregion
- A conserved ~55 kDa subtilisin-like catalytic domain
- A variable carboxyl-terminal domain
Furin becomes catalytically active after proregion cleavage in the appropriate cellular compartment and is the only PC known to possess a transmembrane domain. Cleavage of target proteins occurs at the carboxyl-terminus of the furin consensus sequence RX(K/R)R. The peptide sequence C771PSDSEEDEG780 localizes furin to the trans-Golgi network, and phosphorylation of serine residues in this region modulates intracellular routing. The tetrapeptide Y759KGL762 directs internalization from the cell surface.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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