Thermo Fisher Scientific beta-2 Microglobulin Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.03–0.1 µg/mL

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

Beta-2-microglobulin (B2M) is a 12–14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I.
Human beta-2 Microglobulin associated with HLA Class I antigens is expressed on many cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes.
Beta-2-microglobulin is also found in free form in the plasma. Its amino acid sequence is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta-pleated sheet structure.
The protein is ubiquitously expressed in the cytoplasm and is involved in antigen processing and presentation. It also plays a role in TCR signaling and downstream signaling in naive CD8+ cells.
The B2M gene is located on chromosome 15, and mutations can result in hypercatabolic hypoproteinemia.
Beta-2-microglobulin levels can be used to assess renal function in kidney transplant recipients and serve as a prognostic marker for HIV infection.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.