Thermo Fisher Scientific SPTBN1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Target Information

Spectrin (Sp), the most abundant of the erythrocyte membrane skeleton proteins, helps cells maintain their characteristic biconcave shape while remaining flexible and elastic.
Erythrocyte Sp is a heterodimer composed of a 280 kDa alpha subunit and a 246 kDa beta subunit, which associate in an antiparallel configuration to form a 100 nm rod-like structure.
Spectrin in other tissues may consist of distinct but homologous alpha and beta subunits, sometimes referred to as fodrin.
A newly introduced nomenclature designates the erythrocyte subunits as alpha-1 and beta-1, and the fodrin subunits as alpha-2 and beta-2. Alternatively spliced forms of each are designated as epsilon-1, epsilon-2, etc. (e.g., beta-1 epsilon-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.