Thermo Fisher Scientific CSN7b Polyclonal Antibody
CSN7b 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P)에서 사용 가능. 인간 및 마우스 반응성. 고순도 Affinity chromatography 정제, 1 mg/mL 농도, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human COPS7B (Accession Q9H9Q2), corresponding to amino acid residues D179–Q229 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852450 |
Product Specific Information
Antibody detects endogenous levels of total COPS7B.
Target Information
Component of the COP9 signalosome complex (CSN), which is involved in various cellular and developmental processes.
The CSN complex regulates the ubiquitin (Ubl) conjugation pathway by mediating deneddylation of cullin subunits of SCF-type E3 ligase complexes, thereby decreasing their Ubl ligase activity.
It is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1, and IRF8/ICSBP, possibly via association with CK2 and PKD kinases.
CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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