Thermo Fisher Scientific COPS7A Polyclonal Antibody
COPS7A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인체, 마우스, 랫트 반응성. 고순도 Affinity Chromatography 정제, PBS/glycerol buffer 보존, 연구용 전용 제품.
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Thermo Fisher Scientific COPS7A Polyclonal Antibody
Applications and Tested Dilutions
- Western Blot (WB): 1:1,000–1:3,000
- Immunohistochemistry (Paraffin) (IHC-P): 1:50–1:200
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human COPS7A (Accession Q9UBW8), corresponding to amino acid residues D234–N275 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852449 |
Product Specific Information
This antibody detects endogenous levels of total COPS7A.
Target Information
The COP9 signalosome (CSN) complex is involved in various developmental and cellular processes. It consists of multiple widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b), and CSN8 (COP8).
The CSN complex regulates the ubiquitin conjugation pathway by mediating deneddylation of SCF-type E3 ligase complexes, reducing ubiquitin ligase activity. It is also involved in phosphorylation of p53, c-Jun, IκB-alpha, and IRF-8. CSN-dependent phosphorylation of p53 and c-Jun protects and promotes degradation via the Ubl system.
CSN7 is phosphorylated by CK2 and consists of two subunits, a and b. CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region and a coiled-coil region, predicted to interact with CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7b contains only a PCI region and is predicted to interact with INT6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-103079_COPS7A_Q9UBW8-1_Rabbit.svg, PA5-103079_COPS7A_Q9UBW8-1_Rabbit_PDP.jpeg)
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