Thermo Fisher Scientific CRP Polyclonal Antibody

Thermo Fisher Scientific CRP Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CRP (C-reactive protein) is a major cyclic, pentameric acute phase protein composed of five identical, noncovalently bound, nonglycosylated subunits. Each subunit consists of 206 amino acids with a molecular weight of 24 kDa.
CRP is produced by the liver and its plasma levels rise dramatically during inflammatory processes. It initiates the classical complement cascade, binds to nuclear components (chromatin, histones, etc.), and plays an important role in innate immunity.
CRP acts as an opsonin and activator of monocytes/macrophages, binding to nuclear components such as chromatin, histones, and snRNP, suggesting a scavenger role during cell necrosis.
It contributes to host defense by recognizing foreign pathogens and damaged host cells, initiating their elimination via humoral and cellular effector systems. Elevated basal CRP levels are associated with increased risk of hypertension and cardiovascular disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.