Thermo Fisher Scientific Placental Alkaline Phosphatase Polyclonal Antibody
인체 PLAP 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 적합합니다. 0.2 mg/mL 농도의 액상 형태이며 Protein A로 정제되었습니다. 인간 시료 반응성이 높고, 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Placental Alkaline Phosphatase Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified PLAP from human placenta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1958686 |
Product Specific Information
- Recommended positive control: Third Trimester Placenta.
Target Information
Placental Alkaline Phosphatase (PLAP) plays an important role in regulating specific inflammatory disease processes. There are four related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney isoforms. PLAP reacts with a membrane-bound isoenzyme (Regan and Nagao type) occurring in the placenta during the 3rd trimester of gestation.
PLAP is useful for identifying testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA).
A proposed function of PLAP is matrix mineralization; however, mice lacking a functional form show normal skeletal development. PLAP has been linked to hypophosphatasia, a disorder characterized by hypercalcemia and skeletal defects. The severity and onset depend on the specific mutation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA1-29125_Placental_Alkaline_Phosphatase_P05187-1_Rabbit.svg
- PA1-29125_Placental_Alkaline_Phosphatase_P05187-1_Rabbit_PDP.jpeg
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