Thermo Fisher Scientific Claudin 2 Polyclonal Antibody
Claudin-2 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 ELISA에 적합하며, 세포막 및 tight junction 단백질 연구에 활용됩니다. -20°C 보관, Affinity 정제 방식으로 고순도 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 184–230 of human CLDN2 (NP_001164563.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.83 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2805690 |
Product Specific Information
- Positive Samples: Mouse liver, Mouse lung
- Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, tight junction
- Immunogen sequence:
SCSSQRNRSN YYDAYQAQPL ATRSSPRPGQ PPKVKSEFNS YSLTGYV
Target Information
Tight junctions are specialized regions of cell-cell contact abundant in luminal epithelial sheets. In freeze-fracture electron micrographs, they appear as belt-like bands of sealing strands that encircle the lateral surfaces of cells. These strands interact to form a molecular gasket preventing ions, water, and molecules from leaking between cells.
Beyond the barrier function, tight junctions maintain epithelial polarity by blocking diffusion of membrane proteins between apical and basolateral surfaces. Several peripheral membrane proteins (ZO-1, ZO-2, ZO-3, cingulin, Rab-3b, symplekin) are involved in assembly, maintenance, and permeability regulation. Actin filaments also play a major role in regulating tight junction permeability.
Claudin-1 and Claudin-2 are key structural components of tight junction strands. Claudin-2 functions as a paracellular channel selective for cations (Na+), mainly expressed in liver and kidney, with minor expression in the brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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