Thermo Fisher Scientific Phospho-ETS1 (Thr38) Polyclonal Antibody
Phospho-ETS1 (Thr38) 특이적 폴리클로날 항체로, Western blot 및 IHC, ICC/IF 분석에 적합합니다. Rabbit IgG 기반으로 항원 친화 크로마토그래피로 정제되었으며, 다양한 종에서 반응성을 보입니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 5 publications |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Rabbit, Rat, Xenopus |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human ETS1 that contains threonine 38. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533574 |
Target Information
ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); ETS-1; EWSR2; p54) is a 441 amino acid protein and a member of the DNA-binding ETS family. It consists of an N-terminal pointed domain, a central transactivation domain, and two auto-inhibitory domains flanked by a conserved C-terminal Ets domain. ETS1 interacts with factors such as PEBP2alphaA and p300/CBP, and mediates transactivation of Osteopontin, Presenilin-1, Stromelysin, and Collagenase. It is activated by Ras/MAPK signaling and upregulated in resting T-cells. Activity is modulated by AP-1, Sp-1, c-myb, and MafB. Sp100 activates ETS1 in nuclear bodies, while interactions with EAP1/Daxx repress MMP1 and BCL2 transactivation. ETS1 also interacts with STAT6 to modulate Socs-1 expression induced by IL-4 and with GATA3 to positively regulate Tax-1 dependent IL-5 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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