Thermo Fisher Scientific Phospho-ETS1 (Ser282) Polyclonal Antibody
Phospho-ETS1 (Ser282)을 인식하는 Rabbit Polyclonal Antibody로, Western Blot에 최적화되어 있습니다. Human 시료에서 검증되었으며, 비결합(Unconjugated) 형태의 액상 제품입니다. -20°C에서 보관하며, 연구용으로만 사용 가능합니다.
- 카탈로그번호
- 441109G
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human ETS1 that contains serine 282. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2533577 |
Target Information
ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); ETS-1; EWSR2; p54)
ETS1 is a 441 amino acid DNA-binding protein belonging to the ETS family. It contains an N-terminal pointed domain, a central transactivation domain, and two auto-inhibitory domains flanking the conserved C-terminal ETS domain. ETS1 interacts with transcription factors such as PEBP2alphaA and p300/CBP, mediating transactivation of genes including Osteopontin, Presenilin-1, Stromelysin, and Collagenase. Activated by Ras/MAPK signaling, ETS1 expression increases in resting T-cells and is regulated by factors such as AP-1, Sp-1, c-myb, and MafB. It is also activated by Sp100 in nuclear bodies and interacts with EAP1/Daxx, STAT6, and GATA3, influencing gene expression including MMP1, BCL2, Socs-1, and IL-5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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