Thermo Fisher Scientific Phospho-PRAS40 (Thr246) Polyclonal Antibody
PRAS40 단백질의 Thr246 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 10 publications |
| Immunohistochemistry (IHC) | Assay-dependent | View 4 publications |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Immunoprecipitation (IP) | - | View 1 publication |
| Dot Blot (DB) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from the region of human PRAS40 containing threonine 246 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533573 |
Product Specific Information
The antibody has been negatively preadsorbed using a non-phosphopeptide corresponding to the phosphorylation site to remove reactivity with non-phosphorylated PRAS40.
The final product is generated by affinity chromatography using a PRAS40-derived peptide phosphorylated at threonine 246.
This antibody has been used in western blotting with NIH3T3 cells ± PDGF as a positive control. Previous lots have been used in immunocytochemistry and immunohistochemistry. Other applications may work but have not been tested.
Target Information
The Akt signaling pathway regulates apoptosis in response to various cell death signals.
AKT1S1 (PRAS40) is a proline-rich substrate of AKT1 and plays a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia.
It is also a substrate and regulator of mTOR, which controls cell growth and cycle, and acts as a negative regulator of autophagy.
Treatment with insulin-like growth factor-1 (IGF1) induces phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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