Thermo Fisher Scientific CDC37 Polyclonal Antibody
CDC37 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 최적화되어 있으며, 인간 시료에 반응. Protein A로 정제된 액상 형태로, 안정적 저장 및 높은 재현성 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Native human Cdc37, full length |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.68 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2735618 |
Product Specific Information
A 1:2,000 dilution of PA5-77802 was sufficient for detection of Cdc37 in 20 µg of HeLa cell lysate by ECL immunoblot analysis. Detects approximately 44.5 kDa.
Target Information
In S. cerevisiae, Cdc37 is an important regulator of the cell division cycle through its action on cyclin-dependent kinases (CDKs). It is also associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase, and the sevenless receptor tyrosine kinase.
HSP90 has been shown to associate with many of the same cellular targets as Cdc37. Cdc37, also known as p50, forms complexes with Src-family kinases (Fyn, Yes, Fes, Lck, and Fgr), Raf, and pp60v-src. Cdc37 functions as a chaperone both independently and in concert with HSP90, and is necessary for the binding of HSP90 to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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