Thermo Fisher Scientific NPR-B Polyclonal Antibody
NPR-B 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 생쥐, 랫트 시료에 반응. WB, IHC, ICC, ELISA 등 다양한 응용 가능. 고순도 Protein A 정제, 액상 형태로 안정적. 연구용으로만 사용.
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Thermo Fisher Scientific NPR-B Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human NPR-B, amino acids 101–200 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes natriuretic peptide receptor B (NPR-B), one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains:
- Extracellular ligand-binding domain
- Single membrane-spanning region
- Intracellular protein kinase homology domain
- Helical hinge region involved in oligomerization
- Carboxyl-terminal guanylyl cyclase catalytic domain
The protein is the primary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene cause acromesomelic dysplasia Maroteaux type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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