Thermo Fisher Scientific CD177 Polyclonal Antibody
CD177 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 ELISA에 사용 가능. 인간 및 생쥐 시료에 반응하며, 세포막 GPI-앵커 단백질 연구에 적합. 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공.
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- PA593050
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 35–285 of human CD177 (NP_0651392) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.74 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806603 |
Product Specific Information
Immunogen sequence:
VSDLPRQWTP KNTSCDSGLG CQDTLMLIES GPQVSLVLSK GCTEAKDQEP RVTEHRMGPG LSLISYTFVC RQEDFCNNLV NSLPLWAPQP PADPGSLRCP VCLSMEGCLE GTTEEICPKG TTHCYDGLLR LRGGGIFSNL RVQGCMPQPV CNLLNGTQEI GPVGMTENCD MKDFLTCHRG TTIMTHGNLA QEPTDWTTSN TEMCEVGQVC QETLLLLDVG LTSTLVGTKG CSTVGAQNSQ KTTIHSAPPG V
Positive Samples: BT-474
Cellular Location: Cell membrane, GPI-anchor, Lipid-anchor
Target Information
CD177 (also known as NB1/HNA-2a and PRV-1 form) is a GPI-anchored glycoprotein primarily expressed on neutrophils. Its plasma membrane expression increases during pregnancy, inflammation, or after G-CSF application. CD177 binds to CD31 (PECAM-1) and plays a role in neutrophil transmigration and proliferation. Antibodies against CD177 are associated with neonatal alloimmune neutropenia (NAN).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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