Thermo Fisher Scientific CD44 Monoclonal Antibody (OTI2E3), TrueMAB
CD44 단백질을 인식하는 Mouse monoclonal antibody로, Human 및 Dog 시료에 반응합니다. IHC(P)에서 1:150 희석 비율로 검증되었으며, Lyophilized 형태로 제공됩니다. 세포 접착 및 이동 관련 연구에 적합합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E3 |
| Immunogen | Full-length human recombinant protein of human CD44 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, an additional desalting step is recommended (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
CD44 is a 100 kDa type I transmembrane glycoprotein expressed on human leukocytes, brain white matter, and various epithelial tissues. It serves as a receptor for hyaluronic acid (HA) and plays roles in cell-cell interactions, adhesion, and migration. CD44 is involved in lymphocyte activation, recirculation, and homing. Expression levels may increase in certain carcinomas, potentially linked to metastatic potential.
CD44 exists in multiple isoforms due to alternative splicing, contributing to its structural and functional diversity. It is expressed in hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia of cultured keratinocytes. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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