Thermo Fisher Scientific DEFB121 Polyclonal Antibody
인간, 마우스, 랫트에 반응하는 DEFB121 폴리클로날 항체. IHC 및 ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human DEFB121 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719724 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen, and the purity is greater than 95% (by SDS-PAGE).
Target Information
Beta-defensins (BDs or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against enveloped viruses, fungi, and bacteria. They are produced in mucosal epithelia and neutrophils of several species and are developmentally regulated.
Beta-defensin proteins share a conserved defensin motif with multiple cysteine residues and a stable tertiary structure. Beyond their role in immune defense, many beta-defensins are involved in sperm maturation and capacitation.
Beta-defensin 121 is a 76-amino-acid secreted protein that likely contains a signal peptide requiring proteolytic cleavage for activation. It is expressed at low levels in testis but abundantly in epididymal caput and corpus, and unlike other beta-defensins, it is not regulated by androgens.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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