Thermo Fisher Scientific DARC Recombinant Rabbit Monoclonal Antibody (10H52L38)
Human DARC 단백질을 인식하는 재조합 토끼 단일클론 항체로, WB 및 ICC/IF에 사용 가능. 높은 특이성과 일관된 품질을 제공하며, 단백질 A 정제 및 PBS 버퍼로 보존. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:5,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10H52L38 |
| Immunogen | Protein corresponding to human DARC [aa1-aa63] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809247 |
Product Specific Information
This antibody is predicted to react with Monkey, Rat, and Rabbit.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal production candidates.
Advantages of recombinant rabbit monoclonal antibodies:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broad immunoreactivity due to large rabbit immune repertoire
Target Information
ACKR1 (also known as DARC) is an atypical chemokine receptor that regulates chemokine levels and localization through high-affinity binding, independent of classical signal transduction. It functions in chemokine sequestration, degradation, and transcytosis.
ACKR1 interacts with inflammatory chemokines of both CXC and CC subfamilies, excluding homeostatic chemokines. It also serves as a receptor for chemokines such as CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC, and for malaria parasites P. vivax and P. knowlesi.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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